From Thinkgeek:
Each of the four glasses in the RPG Drinking Stats Pint Glass 4-Pack is different. For when drink gives you powers, use the +10 Charisma or +10 Wisdom glasses. For when it take your powers away, use the -10 Intelligence or -10 Dexterity glasses. But no matter which glass of the RPG Drinking Stats Pint Glass 4-Pack set you drink from, you will always get -10 Thirst.